About Us

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Guisheng was born in Anqing city of Anhui Province. He began his research career at Anhui University and got his Bachelor degree from Physics. Convinced by the view “21st century belongs to Biology”, without hesitation, Guisheng went to the University of Science and Technology of China to study biophysics. He finally got his PhD degree from Cornell University with Dr. Ron Harris-Warrick to study the cellular mechanism for mammalian locomotion. After graduation, he went to Dr. Xiaowei Zhuang’s lab at Harvard University to have the optic training and to investigate the structure and function of cytoskeleton in neurons. Eventually he had a job at ShanghaiTech University in 2015. Here, he has the continuous research interest in the structure and function of cytoskeleton, with a focus in the auditory system. He is also studying the structure and function of GPCRs, a widely expressed membrane receptors which play a critical role in cellular functions with different technologies, from X-ray crystallography, electron microscope, super-resolution fluorescence imaging to eletrophysiology. He is also interested in the function of natural compounds. Through collaborations, he hopes to find some magic bullets for severe diseases, like cancers and cardiac diseases. Out of the lab,Guisheng plays basketball, ping-pang, soccer and lot of other sports.

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Yan Liu

Research Assistant Professor

Yan received her bachelor degree in Science of Biology from the Central University of Nationalities. She pursued her PhD studies in Tsinghua University and University of Wisconsin-Madison, where she investigated the role of ion-transporters in glia dysfunction and the influence on neurons following cerebral ischemia. She worked as a Lecturer in National University of Defense Technology after graduation. Funded by NSFC, she continued studies on membrane proteins. Yan joined Shanghaitech University in 2015, working with Prof. Zhong Guisheng. She focused on structure and function studies of cytoskeleton proteins/ion transporters under physiological and pathological conditions at the nanometer-scale. By using the superresolution microscopy and other leading technologies, she currently works on deciphering the fundamental nature of auditory system. Yan likes photography, reading, running, and outdoor activities at her spare time.

Publications:

1. Yan Liu#, Douglas B. Kintner#, Vishal Chanana#, Xinzhi Chen, Jehad Algharabli, Peter Ferrazzano, Julia Olson, Dandan Sun. Activation of microglia depends on Na+/H+ exchange-mediated H+ homeostasis. The Journal of Neuroscience, 2010 Nov 10, 30(45): 15210-15220.

2.Yan Liu, Douglas B. Kintner, Samuel Cramer, Jehad Algharabli, Gary E. Shull, Xiang-Jun Liu, and Dandan Sun. ER Ca2+ signaling and mitochondrial Cyt c release in astrocytes following oxygen and glucose deprivation. The Journal of Neurochemistry, 2010 Sep 1; 114(5): 1436-46.

3.Gulnaz Begum, Douglas B. Kintner, Yan Liu, Samuel W. Cramer, and Dandan Sun. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia. The Journal of Neurochemistry, 2012 Jan 13; 120(4): 622-630.

4. Xin-yu Zhang, Lin Shi, Yan Liu, Feng Tian, Hai-tao Zhao, Xiao-ping Miao, Ming-lie Huang, and Xiao-yan Zhu. ICPS: an integrative cancer profiler system. Bioinformatics, 2010 Aug 24; 26(20):2649-2650.

5. Yan Liu, Qian Chen, Yahui Man and Wenjian Wu. Insect olfactory receptors as essential detectors for volatile chemicals in biomimetic odorant sensors. Applied Mechanics and Materials, 2013. vol.461, P834.

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Yunbo Qiao

Research Assistant Professor

Yunbo was born in Yichang, Hubei, where is the Three Gorges located at. He got his bachelor's degree from Wuhan University, where he began his formal research training related to virus. Then, he got his Ph.D. degree from Institutes of Biochemistry and Cell Biology, CAS. During Ph.D. training, he learned how to study signaling pathways and to identify downstream targets in early neural development by using mouse embryonic stem cells as an in vitro model. Then, he began to study epigenetic regulations during human embryonic stem cell differentiation as a postdoctoral fellow, during which he completed several pieces of work related to histone and DNA modifications. Since joining the iHuman Institute at ShanghaiTech in 2016, Yunbo has continued to explore the epigenetic mechanisms in developmental biology and cancer biology combined with high-throughput sequencing technologies.

Publications:

1.Xiongjun Wang#, YunboQiao#, Minzhe Xiao, Lingbo Wang, Jun Chen, Wenjian Lv, Jinsong Li, Naihe Jing#, Y. Eugene Chin1#. Opposite roles of acetylation and serine-phosphorylation in modulating LIFR self-renewal growth signaling in mESCs. Cell Reports. 2017 (Co-first author)

2.Yunbo Qiao, Xianfa Yang, and Naihe Jing. Epigenetic regulation of early neural fate commitment. Cellular and Molecular Life Sciences. 73: 1399. 2016.

3.Yunbo Qiao#, Ran Wang#, Xianfa Yang, Ke Tang, and Naihe Jing*. Dual Roles of Histone H3 Lysine 9 Acetylation in Human Embryonic Stem Cell Pluripotency and Neural Differentiation. J Biol Chem. 290(4): p. 2508-20. 2015.

4.Yunbo Qiao#, Xiongjun Wang#, Ran Wang, Yuanyuan Li, Fang Yu, Xianfa Yang, Lu Song,Guoliang Xu, Y. Eugene Chin*, and Naihe Jing*. AF9 Promotes hESC Neural Differentiation through Recruiting TET2 to Neurodevelopmental Gene Loci for Methylcytosine Hydroxylation. Cell Discovery. 1, 2015.

5.Yunbo Qiao, Yue Zhu, Nengyin Sheng, Jun Chen, Ran Tao,Qingqing Zhu, Ting Zhang, Cheng Qian, and Naihe Jing*. AP2γ regulates neural and epidermal development downstream of the BMP pathway at early stages of ectodermal patterning. Cell Research. 2012; 22(11):1546-61.

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Yuan Liu

Lab Manager

Yuan Liu was born and raised in ShanDong province , is also the hometown of Confucius. In the high school, he found his interest in science, rather than liberal arts. So after the college entrance examination, he majored in the lifescience, including phytology, zoology, microbiology, molecular biology, cytobiology, biochemistry, genetics et al . at ShanDong University for four years. In the next three years, he continued his research careers in Prof. YiHan Chen’s lab at TongJi University, focusing on the pathogenesis of heart disease, especially the regulation of related proteins expression. In 2016,he joined Prof Zhong’s group,to seek the more detailed cytoskeleton structure of cardiomyocytes using super-resolution microscopes. He also cooperate with Simeng ,aiming to explore the cardioprotection effect of natural products. Outside of lab,Yuan Liu love reading ,especially about history and philosophy,and long-distance running.

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Simeng Zhao

Postdoctoral Fellow

Simeng was born and raised in the beautiful villages near the Changbai Mountains in Jilin Province, and he spent his childhood running in the colorful hills and fishing in the clear streams, without worry of exams. He had heard the story of Ginseng, a magical herb, for many years, and he did find one when he was 11 years young. The Ginseng story made Simeng leave home to study Traditional Chinese Medicines (TCMs) at China Pharmaceutical University, Nanjing. However, after four years of organic chemistry, analytical chemistry, biochemisty, and physical chemistry, he realized that he was a chemist rather than a doctor, though his major was “Medicines”. He then decided to be a “Dr.”, and moved to Kunming Institute of Botany, Chinese Academy of Sciences, studying natural product chemistry and chemical biology. Five years later, he got the PhD degree and finally became a “Dr.”. In 2016, Simeng joined Zhong lab, to seek more challenges at the interface of chemistry and biology. He focuses on the functional study of small molecules, especially natural products. Simeng loves hiking, and photography, but now he spends much more time on microscope imaging which is also his favourite.

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Hui Li

Postdoctoral Fellow

Hui was born and raised in a small town in the Zhejiang province with exquisite natural beauty. During undergraduate studies in Central South University, She majored in Bio-technique and became especially interested in neuroscience, which led her to pursue graduate research in the mechanism and pathway of pain at Fudan University. At Fudan University, she worked in Pro. Yuqiu Zhang’s lab exploring the mechanism of morphine tolerance in bone cancer pain animals. After got the Ph. D. degree, Hui joined Zhong’s lab, and focused to investigate the structure and function of GPCRs with super resolution imaging in the central neuronal system. When not in the lab, Hui enjoys spending time with her family and friends, exploring the outdoors, taking in the shows, and playing sports.

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Fangzhi Tan

Postdoctoral Fellow

Fangzhi Tan was born in Songzi city of Hubei Province. He got his Bachelor degree in biology from Huazhong University of Science and Technology. Then, he went to Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, and did his PhD with Prof. Naihe Jing on the early neural development and Alzheimer’s disease. After graduation, he stayed in Prof. Naihe Jing’s lab as an assistant investigator. In February 2017 he arrived in the Zhong lab, where he is using imaging methods to study Alzheimer’s disease.

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Xiaoyu Chen

Graduate Student

Xiaoyu was born in Xingtai city, Hebei Province. Considering her big interest in hiking and plants, she entered College of Environmental Science and Engineering in Nankai University, to learn how to protect our surroundings. At the beautiful campus, she learnt many environmental assays and plant names. Nevertheless, she started to learn biology and found it amazing after the postgraduate exam. In 2014, she joined iHuman Institute of Shanghaitech University where she studies GPCR structure and function by X-ray crystallization, super-resolution imaging and other assays. In her spare time, she loves playing badminton and reading.

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Cenfeng Chu

Graduate Student

Cenfeng is a graduate student of Zhong's Lab. She was born in a scenic city called Xuancheng in Anhui Province. She is a lively girl who looks like a little quiet but actually has a strong heart. In her spare time, she is keen on watching movies and traveling. In addition, she also does some sports like table tennis and jogging. From September 2012 to July 2016, Cenfeng had a great time in Anhui University studying Bioscience. Through undergraduate studies, she found the interest of Neuroscience which made her decide to pursue further studies after receiving bachelor degree. Attracted by the exquisite images of neuronal cytoskeleton in Zhong’s paper, she decided to join in Guisheng Zhong’s lab in 2016. After following years, Cenfeng believes that she will be well equipped not only in academy but also in her life.

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Jie Yang

Graduate Student

Yangjie was born and raised in an ancient hometown near by The Yangtze river in Chongqing which located in southwest of china. The people here are very enthusiastic, kind and positive. She spent a happy childhood in her hometown. After 10 years old, She went for a picnic and barbecue with classmates and teachers by the Yangtze river every Spring. She cooked well and always helpful due to the experiments. She met a great teacher who teaches biology when she was in high school. That makes her interested in learning biology and get high scores in her examinations. But her major is Chemistry in Southwest university, because she wants to be a scientist to study the nanomaterial. Her character was changed during her four years life in southwest university because she is shy before, and She is a sunny and happy girl today. However, after four years of organic chemistry, analytical chemistry, Inorganic chemistry and physical chemistry, she realized that she want to do something she has never contacted. She has a strong desire to do something new. She found a new university which names shanghaitech university in the small wood warm forum, and attended the summer camp. During the summer camp, she met her advisor Prof.Zhong fortunately, and She joined Zhong's lab for one year. With the help of the senior, she finished a review about Stachastic optical reconstruction microscopy (STORM). In addition, she also play badminton, volleyball, and lots of other sports.

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Cuiping Tian

Research Staff

Cuiping got her PhD degree in the institute of neuroscience. She created various improves in the immunostaing of ion channel proteins, and found unique distribution patterns of various channels. With such great staining results, she wanted to “see” those more clearly with more powerful microscopy. After graduation, she joined in the super-resolution imaging facility in the iHuman institute in 2015. She was fascinated by these cut-edge microscope and totally fell in love with them. She provides very professional service to scientists on the microscope detection based on single molecule level. Besides, focus on the cytoskeleton distribution properties, especially in the tissue level, which means much more challenges compared to those in the culture system. Moreover, she wants to disclose the mechanism of disease in the ultra-distribution of certain cytoskeleton and ion channels, such as AD, MS etc. She is also interested in the GPCR and is finding collaboration with other members in the iHuman.

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Xiaowei Ji

Research Staff

Xiaowei was born in Jiujiang city of Jiangxi Province located in the midst of China. She began her research career at Shanxi Medical University and got his Bachelorof Medicine degree. She did not choose to be a doctor or a public health physician but want to doresearch. Then Xiaowei was recommended to Second Military Medical University to study Epidemiology and Medical statistics,and she finally got his master by studying the HBV induced liver diseases including liverfibrosis, liver cirrhosis and hepatocellular carcinoma. After graduation, she started her career as a staff in the bio-imaging core of iHuman institute of ShanghaiTech University. Hereshe continued her study on the ultrastructure of hepatocytes combining the hepatocyte with the super-resolution microscopy such as STORM, SIM and STED, which rarely studied before. She is also studying the alcohol liver diseases and wants to explain the mechanism of the ethanol metabolism in liver.

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Jieyu Qi

Visiting Student

Jieyu was born in Nanyang city of Henan province, where Liu Bei beg Zhuge Liang of talent to give his help. She graduated from a local school called Nanyang Normal University and began her research career later than other contemporaries when she came to Southeast University for successive postgraduate and doctoral programs of study. She was responsible and persistent, and fortunately she met a discerning supervisor who identified her advantages and sent her to Zhong’s lab for a promisingly collaborated study on the cytoskeleton structures of inner ear hair cell by using several super-resolution microscopies in ShanghaiTech University. More ploughing benefited reproductive wheat, as she made considerable strides here, with the guidance of Prof. Zhong and the help of lab members, and finally discovered some bran-newly arranged cytoskeleton structures which may involve in the transmission of sound vibration. How exhilarating!

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Guangyan Zhangyuan

Visiting Student

Guangyan Zhangyuan received his bachelor degree in Nanjing medical university and began his medical career in Jiangsu Province hospital as a postgraduate majoring in Hepatobiliary Surgery. Personally, he thinks that an outstanding doctor is not only a clinical worker, but also a researcher who can unveil the medical secrets and uncover new avenus for therapy of different diseases like cancer, HIV and angiocardiopathy. Therefore, he followed his tutor’s suggestions and began his further study of basic researches as a Joint training student in Shanghaitech University since December 24th,2017. Rome was not built in a day. He believes the dream will come true to be an excellent doctor in the future.

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Li He

Visiting Student

Heli was born and raised in Liaocheng city of Shandong Province. When she was at high school, she was curious about life sciences. She majored in Science of biology in University and learn more things about life. Four years later, she wanted to know more about the science of life. She began her research at Southeast University. Now, she go to Guisheng Zhong'lab to have a training and focus on the project of how to affect structure of cytoskeleton arrangement in neurons by biomaterials.