To understand cellular functions, it is critical to know the structure of many different kinds of components in cells. With the newly development of novel imaging tools, labeling approaches, it is feasible to take this challenge by mapping the connectome of subcellular components. In Zhong’s lab, we aim to create a subcellular map of different components, also named as “the Cell Atlas”, to better understand their function and role in cell biology and disease. Currently, our major research is focused in three areas: 1) the structure and function of cytoskeletons; 2) the structure and function of GPCRs; 3) the function of novel natural compounds.